Absolutely! You can mix them into just about any paint. If you're brushing or rolling the broadcast method will give you a more uniform pattern as overlaps will double up on the particles. Brush/roll a coat, sprinkle evenly over while still wet, allow to dry and blow off excess and brush/roll another thin coat to seal.
You don't want them in the last coat, they will wear through or off too easy......the coat before the last coat.